Opposing Risks of Gastric Cardia and Noncardia Gastric Adenocarcinomas Associated With Helicobacter pylori Seropositivity

2006327 citationsJournal Articlebronze Open Access

Authors

Farin Kamangar · Johns Hopkins University

Sanford M. Dawsey · Johns Hopkins University

Martin J. Blaser · Johns Hopkins University

Guillermo I. Perez-Perez · Johns Hopkins University

Pirjo Pietinen · Johns Hopkins University

Craig J. Newschaffer · Johns Hopkins University

Christian C. Abnet ·

Abstract

H. pylori is a strong risk factor for noncardia gastric cancer but is inversely associated with the risk of gastric cardia cancer. These findings bolster the hypothesis that decreasing H. pylori prevalence during the past century may have contributed to lower rates of noncardia cancer and higher rates of cardia cancer in Western countries.

Topics & Keywords

Helicobacter pylori-related gastroenterology studies Gastric Cancer Management and Outcomes Gastrointestinal disorders and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 98, Issue 20, pp. 1445-1452

DOI: 10.1093/jnci/djj393

Field-Weighted Citation Impact: 15.79