5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

201399 citationsJournal Articlegold Open Access

Authors

Sandra Schmidhofer · University Hospital Regensburg

Claudia Gebhard · University Hospital Regensburg

Reinhard Andreesen · University Hospital Regensburg

Michael Rehli · University Hospital Regensburg

Abstract

The work described here provides definite evidence that TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine initiates targeted, active DNA demethylation in a mature postmitotic myeloid cell type.

Topics & Keywords

Epigenetics and DNA Methylation HIV/AIDS Research and Interventions HIV Research and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 14, Issue 5, pp. R46-R46

DOI: 10.1186/gb-2013-14-5-r46

Field-Weighted Citation Impact: 3.89