Osteoprotegerin Inactivation Accelerates Advanced Atherosclerotic Lesion Progression and Calcification in Older ApoE <sup>−/−</sup> Mice

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Authors

Brian J. Bennett · Dr. M.G.R. Educational and Research Institute

Marta Scatena · Dr. M.G.R. Educational and Research Institute

Elizabeth A. Kirk · Dr. M.G.R. Educational and Research Institute

Marcello Rattazzi · Dr. M.G.R. Educational and Research Institute

Rebecca Varon · Dr. M.G.R. Educational and Research Institute

Michelle M. Averill · Dr. M.G.R. Educational and Research Institute

Abstract

OPG inhibits advanced plaque progression by preventing an increase in lesion size and lesion calcification. OPG may act as a survival factor and may modulate MMP9 production in vascular cells.

Topics & Keywords

Bone Metabolism and Diseases Protease and Inhibitor Mechanisms Biomarkers in Disease Mechanisms

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 26, Issue 9, pp. 2117-2124

DOI: 10.1161/01.atv.0000236428.91125.e6

Field-Weighted Citation Impact: 8.14

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Osteoprotegerin Inactivation Accelerates Advanced Atherosclerotic Lesion Progression and Calcification in Older ApoE <sup>−/−</sup> Mice

Authors

Abstract

Topics & Keywords

Publication Details