Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

2008892 citationsJournal Articlehybrid Open Access

Authors

Carey N. Lumeng · University of Michigan–Ann Arbor

Jennifer B. DelProposto · University of Michigan–Ann Arbor

Daniel J. Westcott · University of Michigan–Ann Arbor

Alan R. Saltiel · University of Michigan–Ann Arbor

Abstract

The shift in the M2a/M1 ATM balance is generated by spatial and temporal differences in the recruitment of distinct ATM subtypes. The obesity-induced switch in ATM activation state is coupled to the localized recruitment of an inflammatory ATM subtype to macrophage clusters from the circulation and not to the conversion of resident M2a macrophages to M1 ATMs in situ.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Immune cells in cancer Adipose Tissue and Metabolism

Publication Details

Published in: Diabetes

Volume 57, Issue 12, pp. 3239-3246

DOI: 10.2337/db08-0872

Field-Weighted Citation Impact: 22.29

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Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

Authors

Abstract

Topics & Keywords

Publication Details