Decreased Cardiac Expression of Vascular Endothelial Growth Factor and Its Receptors in Insulin-Resistant and Diabetic States

2002337 citationsJournal Articlebronze Open Access

Authors

Eva Chou · Harvard University

Izumi Suzuma · Harvard University

Kerrie J. Way · Harvard University

Darren M. Opland · Harvard University

Allen C. Clermont · Harvard University

Keiko Naruse · Harvard University

Kiyoshi Suzuma · Harvard University

Abstract

The results documented for the first time that differential regulation of VEGF and its receptors exist between microvascular and cardiac tissues, which can be regulated by insulin. These results provide a potential explanation for concomitant capillary leakage and neovascularization in the retina and inadequate collateral formation in the myocardium of insulin-resistant and diabetic patients.

Topics & Keywords

Angiogenesis and VEGF in Cancer Apelin-related biomedical research Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 105, Issue 3, pp. 373-379

DOI: 10.1161/hc0302.102143

Field-Weighted Citation Impact: 5.45