Pertactin-Negative Bordetella pertussis Strains: Evidence for a Possible Selective Advantage

2014193 citationsJournal Articlehybrid Open Access

Authors

Stacey W. Martin · Centers for Disease Control and Prevention

Lucia C. Pawloski · Centers for Disease Control and Prevention

Margaret M. Williams · Centers for Disease Control and Prevention

K. Weening · Vermont Department of Health

Chas DeBolt · Washington State Department of Health

Xuan Qin · Seattle Children's Hospital

Laura Reynolds

Abstract

The significant association between vaccination and isolate pertactin production suggests that the likelihood of having reported disease caused by PRN(-) compared with PRN(+) strains is greater in vaccinated persons. Additional studies are needed to assess whether vaccine effectiveness is diminished against PRN(-) strains.

Topics & Keywords

Bacterial Infections and Vaccines Virology and Viral Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Infectious Diseases

Volume 60, Issue 2, pp. 223-227

DOI: 10.1093/cid/ciu788

Field-Weighted Citation Impact: 17.03