Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

2013171 citationsJournal Articlegold Open Access

Authors

Elinor K. Karlsson · Harvard University

Snævar Sigurðsson · Broad Institute

Emma Ivansson · Uppsala University

Rachael Thomas · North Carolina State University

Ingegerd Elvers · Broad Institute

Jason Wright · Broad Institute

Cédric Howald ·

Abstract

Mapping a complex cancer in multiple dog breeds reveals a polygenic spectrum of germline risk factors pointing to specific pathways as drivers of disease.

Topics & Keywords

Genomics and Chromatin Dynamics Chromatin Remodeling and Cancer Virus-based gene therapy research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 14, Issue 12, pp. R132-R132

DOI: 10.1186/gb-2013-14-12-r132

Field-Weighted Citation Impact: 5.98