A variance-stabilizing transformation for gene-expressionmicroarray data

2002473 citationsJournal Articlebronze Open Access

Authors

Blythe Durbin · University of California, Davis

Douglas M. Hawkins · University of Minnesota

David M. Rocke · University of California, Davis

Abstract

We introduce a transformation that stabilizes the variance of microarray data across the full range of expression. Simulation studies also suggest that this transformation approximately symmetrizes microarray data.

Topics & Keywords

Gene expression and cancer classification Gene Regulatory Network Analysis Bioinformatics and Genomic Networks

Publication Details

Published in: Bioinformatics

Volume 18, Issue suppl_1, pp. S105-S110

DOI: 10.1093/bioinformatics/18.suppl_1.s105

Field-Weighted Citation Impact: 12.10

Command Palette

A variance-stabilizing transformation for gene-expressionmicroarray data

Authors

Abstract

Topics & Keywords

Publication Details