Aging of blood can be tracked by DNA methylation changes at just three CpG sites

2014941 citationsJournal Articlegold Open Access

Authors

Carola I. Weidner · RWTH Aachen University

Qiong Lin · RWTH Aachen University

Carmen Koch · RWTH Aachen University

Lewin Eisele · University of Duisburg-Essen

Fabian Beier · RWTH Aachen University

Patrick Ziegler · RWTH Aachen University

Dirk Bauerschlag ·

Abstract

Our epigenetic aging signature provides a simple biomarker to estimate the state of aging in blood. Age-associated DNA methylation changes are counteracted in iPSCs. On the other hand, over-estimation of chronological age in bone marrow failure syndromes is indicative for exhaustion of the hematopoietic cell pool. Thus, epigenetic changes upon aging seem to reflect biological aging of blood.

Topics & Keywords

Epigenetics and DNA Methylation Genomics and Chromatin Dynamics Birth, Development, and Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 15, Issue 2, pp. R24-R24

DOI: 10.1186/gb-2014-15-2-r24

Field-Weighted Citation Impact: 31.75