Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1

200767 citationsJournal Articlehybrid Open Access

Authors

Karine Zaniolo · Centre hospitalier de l'Université Laval

Steeve Leclerc · Centre hospitalier de l'Université Laval

Sylvain L. Guérin · Centre hospitalier de l'Université Laval

Abstract

Our results therefore recognized Sp1 as a target protein of PARP-1 activity, the addition of polymer of ADP-ribose to this transcription factor restricting its positive regulatory influence on gene transcription.

Topics & Keywords

PARP inhibition in cancer therapy Toxin Mechanisms and Immunotoxins Cell death mechanisms and regulation

Publication Details

Published in: BMC Molecular Biology

Volume 8, Issue 1, pp. 96-96

DOI: 10.1186/1471-2199-8-96

Field-Weighted Citation Impact: 1.95

Command Palette

Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1

Authors

Abstract

Topics & Keywords

Publication Details