Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

2008889 citationsJournal Article

Authors

Xinmei Zhang · University of Hong Kong

Dennis C.Y. Yeung · University of Hong Kong

Michal Karpíšek · University of Veterinary Sciences Brno

David Stejskal · Nemocnice Šternberk

Zhiguang Zhou · Central South University

Feng Liu · Audie L. Murphy Memorial VA Hospital

Rachel L.C. Wong

Abstract

FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation.

Topics & Keywords

Fibroblast Growth Factor Research Kruppel-like factors research Epigenetics and DNA Methylation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 57, Issue 5, pp. 1246-1253

DOI: 10.2337/db07-1476

Field-Weighted Citation Impact: 13.24