Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

2014303 citationsJournal Articlegold Open Access

Authors

Liesbeth Geraets · National Institute for Public Health and the Environment

Agnes G. Oomen · National Institute for Public Health and the Environment

Petra Krystek · Philips (Finland)

Nicklas Raun Jacobsen · National Research Centre for the Working Environment

Håkan Wallin · National Research Centre for the Working Environment

Michel Laurentie · Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail

Abstract

Overall, the results of the present oral and IV study indicates very low oral bioavailability and slow tissue elimination. Limited uptake in combination with slow elimination might result in the long run in potential tissue accumulation.

Topics & Keywords

Anesthesia and Neurotoxicity Research Nanoparticle-Based Drug Delivery Nanoparticles: synthesis and applications

Publication Details

Published in: Particle and Fibre Toxicology

Volume 11, Issue 1, pp. 30-30

DOI: 10.1186/1743-8977-11-30

Field-Weighted Citation Impact: 12.01

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Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

Authors

Abstract

Topics & Keywords

Publication Details