Electrophysiological and haemodynamic effects of vernakalant and flecainide in dyssynchronous canine hearts

201410 citationsJournal Articlebronze Open Access

Authors

Lars B. van Middendorp · Maastricht University

Marc Strik · Maastricht University

Patrick Houthuizen · Maastricht University

Marion Kuiper · Maastricht University

Jos G. Maessen · Maastricht University

A. Auricchio · Epatocentro Ticino

Frits W. Prinzen ·

Abstract

Vernakalant prolongs ventricular conduction less than flecainide, but both drugs had a similar, moderate negative effect on ventricular contractility and relaxation. Part of these reductions seems to be related to the increase in dyssynchrony.

Topics & Keywords

Cardiac Arrhythmias and Treatments Cardiac electrophysiology and arrhythmias Atrial Fibrillation Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: EP Europace

Volume 16, Issue 8, pp. 1249-1256

DOI: 10.1093/europace/eut429

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