Characterization of a Recurrent Germ Line Mutation of the <i>E-Cadherin</i> Gene: Implications for Genetic Testing and Clinical Management

In addition to families with a strong history of early-onset DGC, CDH1 mutation screening should be offered to isolated cases of DGC in individuals ages <35 years and for families with multiple cases of LBC, with any history of DGC or unspecified GI malignancies. Prophylactic gastrectomy is potentially a lifesaving procedure and clinical breast screening is recommended for asymptomatic mutation carriers.