Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

20111,084 citationsJournal Article

Authors

Richard K. Henderson

Concepción Jiménez‐González · Research Triangle Park Foundation

David J. C. Constable · Lockheed Martin (United States)

Sarah R. Alston · Research Triangle Park Foundation

Graham G. A. Inglis · Age UK

Gail Fisher · Age UK

James Sherwood · Universities UK

Abstract

Solvents make a large contribution to the environmental impact of manufacturing processes of active pharmaceutical ingredients (API), as well as playing an important role in other chemical industries, with millions of tons used and disposed of each year. GlaxoSmithKline (GSK) has previously reported on the both the development of a GSK solvent selection guide and the incorporation of solvent life cycle inventory and assessment information. The GSK solvent selection guide has been further enhanced by:

Topics & Keywords

Chemistry and Chemical Engineering Process Optimization and Integration Various Chemistry Research Topics

UN Sustainable Development Goals

Responsible consumption and production

Publication Details

Published in: Green Chemistry

Volume 13, Issue 4, pp. 854-854

DOI: 10.1039/c0gc00918k

Field-Weighted Citation Impact: 44.80