Trimethylsilyl iodide as a peptide deblocking agent

1979139 citationsJournal Article

Authors

Abstract

Removal of urethane and benzyl ether blocking groups from peptides is readily accomplished by treatment with trimethylsilyl iodide which is particularly useful for the debenzylation of O-benzyltyrosine without the formation of rearrangement products.

Topics & Keywords

Chemical Synthesis and Analysis Carbohydrate Chemistry and Synthesis Peptidase Inhibition and Analysis

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Journal of the Chemical Society Chemical Communications

DOI: 10.1039/c39790000495

Field-Weighted Citation Impact: 0.57