AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location

2009798 citationsJournal Articlegreen Open Access

Authors

Meizan Lai · University of Pennsylvania

Ethan G. Hughes · University of Pennsylvania

Xiaoyu Peng · University of Pennsylvania

Lei Zhou · University of Pennsylvania

Amy J. Gleichman · University of Pennsylvania

Huidy Shu · University of California San Francisco Medical Center

Sabrina Matà

Abstract

Antibodies to GluR1/2 associate with LE that is often paraneoplastic, treatment responsive, and has a tendency to relapse. Our findings support an antibody-mediated pathogenesis in which patients' antibodies alter the synaptic localization and number of AMPARs.

Topics & Keywords

Autoimmune Neurological Disorders and Treatments RNA regulation and disease Neuroscience and Neuropharmacology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 65, Issue 4, pp. 424-434

DOI: 10.1002/ana.21589

Field-Weighted Citation Impact: 25.73