Mast Cell Tryptase Degrades HDL and Blocks Its Function as an Acceptor of Cellular Cholesterol

200273 citationsJournal Article

Authors

Miriam Lee · University of Münster

Christian P. Sommerhoff · University of Münster

Arnold von Eckardstein · University of Münster

Frank Zettl · University of Münster

Hans Fritz · University of Münster

Petri T. Kovanen · University of Münster

Abstract

By depleting pre-beta-HDL, mast cell tryptase may impair the initial step of reverse cholesterol transport and will then favor cellular accumulation of cholesterol during atherogenesis.

Topics & Keywords

Mast cells and histamine Cholesterol and Lipid Metabolism Retinoids in leukemia and cellular processes

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 22, Issue 12, pp. 2086-2091

DOI: 10.1161/01.atv.0000041405.07367.b5

Field-Weighted Citation Impact: 1.00