Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

2010561 citationsJournal Articlebronze Open Access

Authors

Yanyan Li · University of Michigan–Ann Arbor

Tao Zhang · The Ohio State University

Hasan Körkaya · The Ohio State University

Suling Liu · University of Michigan–Ann Arbor

Hsiu-Fang Lee · University of Michigan–Ann Arbor

Bryan Newman · The Ohio State University

Yanke Yu ·

Abstract

Sulforaphane inhibits breast CSCs and downregulates the Wnt/beta-catenin self-renewal pathway. These findings support the use of sulforaphane for the chemoprevention of breast cancer stem cells and warrant further clinical evaluation.

Topics & Keywords

Genomics, phytochemicals, and oxidative stress Bioactive Compounds and Antitumor Agents Cancer Cells and Metastasis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 16, Issue 9, pp. 2580-2590

DOI: 10.1158/1078-0432.ccr-09-2937

Field-Weighted Citation Impact: 17.04