Novel Mechanism of Antibodies to Hepatitis B Virus in Blocking Viral Particle Release from Cells†

201079 citationsJournal Articlebronze Open Access

Authors

Avidan U. Neumann · Bar-Ilan University

S M Phillips · University College London

Idit Levine · Bar-Ilan University

Samreen Ijaz

Harel Dahari · Bar-Ilan University

Rachel Eren · Protalix BioTherapeutics (Israel)

Shlomo Dagan · Protalix BioTherapeutics (Israel)

Abstract

These results identify a novel antiviral mechanism of antibodies to HBsAg (anti-HBs) involving prolonged blocking of the HBV and HBsAg subviral particles release from infected cells. This may have implications in designing new therapies for patients with chronic HBV infection and may also be relevant in other viral infections.

Topics & Keywords

Hepatitis B Virus Studies Hepatitis C virus research Liver Disease Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 52, Issue 3, pp. 875-885

DOI: 10.1002/hep.23778

Field-Weighted Citation Impact: 2.28