Role of B Cell–Activating Factor in Chronic Obstructive Pulmonary Disease

2015120 citationsJournal Article

Authors

Leen Seys · Ghent University Hospital

Anne Verhamme · Ghent University Hospital

Anja Schuster · AstraZeneca (Sweden)

Hamida Hammad · Ghent University Hospital

Danen Cunoosamy · AstraZeneca (Sweden)

Claudie Bantsimba-Malanda · Altimmune (United States)

Alan Sabirsh ·

Abstract

BAFF is significantly increased in lungs of patients with COPD and is present around both immune and stromal cells within lymphoid follicles. Antagonizing BAFF in CS-exposed mice attenuates pulmonary inflammation and alveolar destruction.

Topics & Keywords

Immune Cell Function and Interaction IL-33, ST2, and ILC Pathways Asthma and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 192, Issue 6, pp. 706-718

DOI: 10.1164/rccm.201501-0103oc

Field-Weighted Citation Impact: 4.98