Rho-GDP dissociation inhibitor alpha downregulated by low shear stress promotes vascular smooth muscle cell migration and apoptosis: a proteomic analysis

200874 citationsJournal Article

Authors

Ying‐Xin Qi · Shanghai Jiao Tong University

Mingjuan Qu · Shanghai Jiao Tong University

Ding-Kun Long · Shanghai Jiao Tong University

Bo Liu · Shanghai Jiao Tong University

Qing‐Ping Yao · Shanghai Jiao Tong University

Shu Chien · Shanghai Jiao Tong University

Zong‐Lai Jiang ·

Abstract

The results indicate that the LSS-induced VSMC migration and apoptosis are mediated by a downregulation of Rho-GDIalpha. The effect of Rho-GDIalpha on VSMC migration is mediated by the PI3K/Akt pathway, but its effect on VSMC apoptosis is not.

Topics & Keywords

Protein Kinase Regulation and GTPase Signaling Metabolism, Diabetes, and Cancer Caveolin-1 and cellular processes

UN Sustainable Development Goals

Decent work and economic growth

Publication Details

Published in: Cardiovascular Research

Volume 80, Issue 1, pp. 114-122

DOI: 10.1093/cvr/cvn158

Field-Weighted Citation Impact: 2.15