Genistein Improves Neuropathology and Corrects Behaviour in a Mouse Model of Neurodegenerative Metabolic Disease

2010138 citationsJournal Articlegold Open Access

Authors

Marcelina Malinowska · University of Gdańsk

Fiona L. Wilkinson · University of Manchester

Kia Langford‐Smith · University of Manchester

Alex Langford-Smith · University of Manchester

Jillian R. Brown

Brett E. Crawford

Marie T. Vanier · Inserm

Grzegorz Grynkiewicz

Abstract

Genistein may prove useful as a substrate reduction agent to delay clinical onset of MPSIIIB and, due to its multimodal action, may provide a treatment adjunct for several other neurodegenerative metabolic diseases.

Topics & Keywords

Lysosomal Storage Disorders Research Child Nutrition and Feeding Issues Glycogen Storage Diseases and Myoclonus

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 5, Issue 12, pp. e14192-e14192

DOI: 10.1371/journal.pone.0014192

Field-Weighted Citation Impact: 7.20