Cognitive Function at 3 Years of Age after Fetal Exposure to Antiepileptic Drugs

2009814 citationsJournal Articlebronze Open Access

Authors

Kimford J. Meador · Woodruff Health Sciences Center

Gus A. Baker · University of Liverpool

N. Andrew Browning · Emmes (United States)

Jill Clayton‐Smith · St. Mary's Hospital

Deborah T. Combs‐Cantrell · The University of Texas Southwestern Medical Center

Morris J. Cohen · Augusta University

Laura A. Kalayjian

Abstract

In utero exposure to valproate, as compared with other commonly used antiepileptic drugs, is associated with an increased risk of impaired cognitive function at 3 years of age. This finding supports a recommendation that valproate not be used as a first-choice drug in women of childbearing potential.

Topics & Keywords

Pharmacological Effects and Toxicity Studies Pregnancy and Medication Impact Epilepsy research and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 360, Issue 16, pp. 1597-1605

DOI: 10.1056/nejmoa0803531

Field-Weighted Citation Impact: 111.63