C/EBP Homologous Protein Deficiency Attenuates Myocardial Reperfusion Injury by Inhibiting Myocardial Apoptosis and Inflammation

2011142 citationsJournal Articlebronze Open Access

Authors

Yuji Miyazaki · IRYO Sosei University

Koichi Kaikita · IRYO Sosei University

Motoyoshi Endo · IRYO Sosei University

Eiji Horio · IRYO Sosei University

Mitsutoshi Miura · IRYO Sosei University

Kenichi Tsujita · IRYO Sosei University

Seiji Hokimoto ·

Abstract

The ER stress-induced, CHOP-mediated pathway, which is activated in part by superoxide overproduction after reperfusion, exacerbates myocardial ischemia/reperfusion injury by inducing cardiomyocyte apoptosis and myocardial inflammation.

Topics & Keywords

Endoplasmic Reticulum Stress and Disease Cardiac Ischemia and Reperfusion Adenosine and Purinergic Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 31, Issue 5, pp. 1124-1132

DOI: 10.1161/atvbaha.111.224519

Field-Weighted Citation Impact: 4.96