Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties

2004675 citationsJournal Articlegreen Open Access

Authors

Charles Antzelevitch · C3J Therapeutics (United States)

Luiz Belardinelli · Masonic Medical Research Laboratory

Andrew C. Zygmunt · C3J Therapeutics (United States)

Alexander Burashnikov · Masonic Medical Research Laboratory

José M. Di Diego · Masonic Medical Research Laboratory

Jeffrey Fish · MACOM (United States)

Jonathan M. Cordeiro

Abstract

Ranolazine produces ion channel effects similar to those observed after chronic amiodarone (reduced I(Kr), I(Ks), late I(Na), and I(Ca)). The actions of ranolazine to suppress EADs and reduce TDR suggest that, in addition to its antianginal actions, the drug may possess antiarrhythmic activity.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Electrochemical Analysis and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 110, Issue 8, pp. 904-910

DOI: 10.1161/01.cir.0000139333.83620.5d

Field-Weighted Citation Impact: 20.03