Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis

20082,923 citationsJournal Articlebronze Open Access

Authors

Frank M. Brunkhorst · Friedrich Schiller University Jena

Christoph Engel · Leipzig University

Frank Bloos · Friedrich Schiller University Jena

Andreas Meier‐Hellmann · Helios Klinikum Erfurt

Max Ragaller · Otto-von-Guericke University Magdeburg

Norbert Weiler · University of Lübeck

Onnen Moerer

Abstract

The use of intensive insulin therapy placed critically ill patients with sepsis at increased risk for serious adverse events related to hypoglycemia. As used in this study, HES was harmful, and its toxicity increased with accumulating doses. (ClinicalTrials.gov number, NCT00135473.)

Topics & Keywords

Hyperglycemia and glycemic control in critically ill and hospitalized patients Diabetes Management and Research Sepsis Diagnosis and Treatment

UN Sustainable Development Goals

Zero hungerGood health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 358, Issue 2, pp. 125-139

DOI: 10.1056/nejmoa070716

Field-Weighted Citation Impact: 189.88