Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure

2012215 citationsReviewbronze Open Access

Authors

Marcus R. Munafò · National Institute on Drug Abuse

Maria Timofeeva · National Institute on Drug Abuse

Richard Morris · National Institute on Drug Abuse

David Prieto‐Merino · National Institute on Drug Abuse

Naveed Sattar · National Institute on Drug Abuse

Paul Brennan · National Institute on Drug Abuse

Elaine Johnstone

Abstract

Our data show a stronger association of rs1051730-rs16969968 genotype with objective measures of tobacco exposure compared with self-reported cigarette consumption. The association of these variants with lung cancer risk is likely to be mediated largely, if not wholly, via tobacco exposure.

Topics & Keywords

Smoking Behavior and Cessation Nicotinic Acetylcholine Receptors Study Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 104, Issue 10, pp. 740-748

DOI: 10.1093/jnci/djs191

Field-Weighted Citation Impact: 13.66