Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

20081,540 citationsJournal Articlebronze Open Access

Authors

Sanford Levine · University of Pennsylvania

Taitan Nguyen

Nyali Taylor

Michael E. Friscia

Murat T. Budak · University of Pennsylvania

Abstract

The combination of 18 to 69 hours of complete diaphragmatic inactivity and mechanical ventilation results in marked atrophy of human diaphragm myofibers. These findings are consistent with increased diaphragmatic proteolysis during inactivity.

Topics & Keywords

Respiratory Support and Mechanisms Congenital Diaphragmatic Hernia Studies Neonatal Respiratory Health Research

Publication Details

Published in: New England Journal of Medicine

Volume 358, Issue 13, pp. 1327-1335

DOI: 10.1056/nejmoa070447

Field-Weighted Citation Impact: 54.26

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Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

Authors

Abstract

Topics & Keywords

Publication Details