Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery

20107,093 citationsJournal Articlebronze Open Access

Authors

Martin B. Leon · NewYork–Presbyterian Hospital

Craig R. Smith · New York Hospital Queens

Michael J. Mack · Medical City Dallas Hospital

D. Craig Miller · Stanford University

Jeffrey W. Moses · New York Hospital Queens

Lars G. Svensson · Cleveland Clinic

E. Murat Tuzcu ·

Abstract

In patients with severe aortic stenosis who were not suitable candidates for surgery, TAVI, as compared with standard therapy, significantly reduced the rates of death from any cause, the composite end point of death from any cause or repeat hospitalization, and cardiac symptoms, despite the higher incidence of major strokes and major vascular events. (Funded by Edwards Lifesciences; ClinicalTrials.gov number, NCT00530894.).

Topics & Keywords

Cardiac Valve Diseases and Treatments Cardiovascular Function and Risk Factors Infective Endocarditis Diagnosis and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 363, Issue 17, pp. 1597-1607

DOI: 10.1056/nejmoa1008232

Field-Weighted Citation Impact: 292.42