A novel snake venom‐derived <scp>GPIb</scp> antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury

201566 citationsJournal Articlebronze Open Access

Authors

Tingting Li · Anhui Medical University

Man‐Li Fan · Anhui Medical University

Shi‐Xiang Hou · Anhui Medical University

Xiaoyi Li · Anhui Transport Consulting & Design Institute (China)

Devin M. Barry · Washington University in St. Louis

Hui Jin · Jiangsu Changjiang Electronics Technology (China)

Shengyong Luo

Abstract

Our data indicate anfibatide is a safe GPIb antagonist that exerts a protective effect on cerebral ischaemia and reperfusion injury. Anfibatide is a promising candidate that could be beneficial for the treatment of ischaemic stroke.

Topics & Keywords

Venomous Animal Envenomation and Studies Platelet Disorders and Treatments Blood Coagulation and Thrombosis Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 172, Issue 15, pp. 3904-3916

DOI: 10.1111/bph.13178

Field-Weighted Citation Impact: 4.13