Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

20144,627 citationsJournal Articlebronze Open Access

Authors

Siddhartha Jaiswal · Dana-Farber Brigham Cancer Center

Pierre Fontanillas · Massachusetts Institute of Technology

Jason Flannick · Massachusetts Institute of Technology

Alisa K. Manning · Broad Institute

Peter Grauman

Brenton G. Mar

R. Coleman Lindsley

Craig H. Mermel · Brigham and Women's Hospital

Abstract

Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease. (Funded by the National Institutes of Health and others.).

Topics & Keywords

Acute Myeloid Leukemia Research Cancer Genomics and Diagnostics Chronic Lymphocytic Leukemia Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 371, Issue 26, pp. 2488-2498

DOI: 10.1056/nejmoa1408617

Field-Weighted Citation Impact: 135.43

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