Increased Mortality after Dronedarone Therapy for Severe Heart Failure

2008960 citationsJournal Articlebronze Open Access

Authors

Lars Køber · University of Copenhagen

Christian Torp‐Pedersen · Gentofte Hospital

John J.V. McMurray

Ole Gøtzsche · Aarhus University Hospital

Samuel Lévy · Hôpital Nord

Harry J.G.M. Crijns · Maastricht University Medical Centre

Jan Amlie

Jan E. Carlsen

Abstract

In patients with severe heart failure and left ventricular systolic dysfunction, treatment with dronedarone was associated with increased early mortality related to the worsening of heart failure. (ClinicalTrials.gov number, NCT00543699.)

Topics & Keywords

Cardiac electrophysiology and arrhythmias Cardiac Imaging and Diagnostics Cardiac pacing and defibrillation studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 358, Issue 25, pp. 2678-2687

DOI: 10.1056/nejmoa0800456

Field-Weighted Citation Impact: 62.70