Heparanase Gene Silencing, Tumor Invasiveness, Angiogenesis, and Metastasis

2004237 citationsJournal Articlebronze Open Access

Authors

Evgeny Edovitsky · Hadassah Medical Center

Abstract

The association of reduced levels of heparanase and altered tumorigenic properties in cells with anti-heparanase ribozyme- or siRNA-mediated gene-silencing vectors suggests that heparanase is important in cancer progression. Heparanase gene silencing has potential use as a target for anticancer drug development.

Topics & Keywords

Proteoglycans and glycosaminoglycans research Glycosylation and Glycoproteins Research Peptidase Inhibition and Analysis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 96, Issue 16, pp. 1219-1230

DOI: 10.1093/jnci/djh230

Field-Weighted Citation Impact: 7.63