Autoimmunity Correlates With Tumor Regression in Patients With Metastatic Melanoma Treated With Anti–Cytotoxic T-Lymphocyte Antigen-4

20051,009 citationsJournal Articlebronze Open Access

Authors

Peter Attia · National Cancer Institute

Giao Q. Phan · National Cancer Institute

Ajay V. Maker · National Cancer Institute

Michael R. Robinson · National Cancer Institute

Martha Quezado · National Cancer Institute

James Chih‐Hsin Yang · National Cancer Institute

Richard M. Sherry

Abstract

Administration of anti-CTLA-4 monoclonal antibody plus peptide vaccination can cause durable objective responses, which correlate with the induction of autoimmunity, in patients with metastatic melanoma.

Topics & Keywords

Immunotherapy and Immune Responses Cancer Immunotherapy and Biomarkers vaccines and immunoinformatics approaches

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 23, Issue 25, pp. 6043-6053

DOI: 10.1200/jco.2005.06.205

Field-Weighted Citation Impact: 20.42