An IAP-IAP Complex Inhibits Apoptosis

2004402 citationsJournal Articlehybrid Open Access

Authors

Takehiko Dohi · University of Massachusetts Chan Medical School

Kazuya Okada · Sanford Burnham Prebys Medical Discovery Institute

Fang Xia · University of Massachusetts Chan Medical School

Casey E. Wilford · University of Massachusetts Chan Medical School

Temesgen Samuel · Sanford Burnham Prebys Medical Discovery Institute

Kate Welsh · Sanford Burnham Prebys Medical Discovery Institute

Abstract

Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP(-/-) cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis.

Topics & Keywords

Cell death mechanisms and regulation Cancer-related Molecular Pathways Autophagy in Disease and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Biological Chemistry

Volume 279, Issue 33, pp. 34087-34090

DOI: 10.1074/jbc.c400236200

Field-Weighted Citation Impact: 6.23