Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

20093,019 citationsJournal Articlebronze Open Access

Authors

Supachai Rerks‐Ngarm · Ministry of Public Health

Punnee Pitisuttithum · Mahidol University

Sorachai Nitayaphan · Armed Forces Research Institute of Medical Science

Jaranit Kaewkungwal · Mahidol University

Joseph Chiu · Armed Forces Research Institute of Medical Science

Robert Paris · Institute of Medical Sciences

Nakorn Premsri

Abstract

This ALVAC-HIV and AIDSVAX B/E vaccine regimen may reduce the risk of HIV infection in a community-based population with largely heterosexual risk. Vaccination did not affect the viral load or CD4+ count in subjects with HIV infection. Although the results show only a modest benefit, they offer insight for future research. (ClinicalTrials.gov number, NCT00223080.)

Topics & Keywords

HIV Research and Treatment vaccines and immunoinformatics approaches Viral Infections and Outbreaks Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 361, Issue 23, pp. 2209-2220

DOI: 10.1056/nejmoa0908492

Field-Weighted Citation Impact: 93.84