Polymerase γ Gene POLG Determines the Risk of Sodium Valproate-Induced Liver Toxicity

2010234 citationsJournal Articlebronze Open Access

Authors

Joanna D. Stewart · Wellcome Centre for Mitochondrial Research

Rita Horváth · Wellcome Centre for Mitochondrial Research

Enrico Baruffini · University of Parma

Iliana Ferrero · University of Parma

Stefanie Bulst · Friedrich Baur Stiftung

Paul B. Watkins · University of North Carolina at Chapel Hill

Robert J. Fontana

Abstract

These findings implicate impaired liver regeneration in VPA toxicity and show that prospective genetic testing of POLG will identify individuals at high risk of this potentially fatal consequence of treatment.

Topics & Keywords

Pharmacological Effects and Toxicity Studies HIV/AIDS drug development and treatment Boron Compounds in Chemistry

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 52, Issue 5, pp. 1791-1796

DOI: 10.1002/hep.23891

Field-Weighted Citation Impact: 21.60