Efficient Synthesis of 2-Ethoxycarbonyl Indoles

200929 citationsJournal Article

Authors

Aralihalli Sudhakara · Kuvempu University

Vijaykumar Hulikal · Centre for Development of Telematics

Abstract

Abstract An efficient one-pot procedure for the synthesis of 2-ethoxycarbonyl indoles from commercially available materials has been developed. The one-step procedure involves in situ formation of the hydrazones from phenylhydrazine hydrochloride and ethyl pyruvate in the presence of bismuth nitrate followed by Fischer cyclization in polyphosphoric acid and ethanol. This method is efficient and simple.

Topics & Keywords

Asymmetric Synthesis and Catalysis Synthesis of Indole Derivatives Chemical Synthesis and Analysis

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Synthetic Communications

Volume 39, Issue 14, pp. 2506-2515

DOI: 10.1080/00397910802656059

Field-Weighted Citation Impact: 1.33