Role of CXCL13 in Cigarette Smoke–induced Lymphoid Follicle Formation and Chronic Obstructive Pulmonary Disease

2013115 citationsJournal Article

Authors

Ken R. Bracke · Ghent University Hospital

Anne Verhamme · Ghent University Hospital

Leen Seys · Ghent University Hospital

Claudie Bantsimba-Malanda · Altimmune (United States)

Danen Cunoosamy · AstraZeneca (Sweden)

Ronald Herbst · Altimmune (United States)

Hamida Hammad ·

Abstract

CXCL13 is produced within lymphoid follicles of patients with COPD and is crucial for the formation of TLOs. Neutralization of CXCL13 partially protects mice against CS-induced inflammation in bronchoalveolar lavage and alveolar wall destruction.

Topics & Keywords

Chronic Obstructive Pulmonary Disease (COPD) Research Asthma and respiratory diseases Pediatric health and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 188, Issue 3, pp. 343-355

DOI: 10.1164/rccm.201211-2055oc

Field-Weighted Citation Impact: 8.29