The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia

2012105 citationsJournal Articlegold Open Access

Authors

Xiaolu Zhang · Qilu Hospital of Shandong University

Jiping Zeng · Shandong University

Minran Zhou · Qilu Hospital of Shandong University

Bingnan Li · Shandong University

Yuanyuan Zhang · Qilu Hospital of Shandong University

Tao Huang · Shandong University

Lixiang Wang ·

Abstract

Taken together, miR-370 may function as a tumor suppressor by targeting FoxM1, and the epigenetic silence of miR-370 thus leads to derepression of FoxM1 expression and consequently contributes to AML development and progression.

Topics & Keywords

MicroRNA in disease regulation FOXO transcription factor regulation Circular RNAs in diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Cancer

Volume 11, Issue 1, pp. 56-56

DOI: 10.1186/1476-4598-11-56

Field-Weighted Citation Impact: 4.43