Expression and prognostic significance of fibronectin and matrix metalloproteases in breast cancer metastasis

2013149 citationsJournal Article

Authors

Belén Fernández‐García · Fundación Hospital de Jove

Noemí Eiró · Fundación Hospital de Jove

Laura Marín · Fundación Hospital de Jove

Salomé González‐Reyes · Fundación Hospital de Jove

Luis O. González · Fundación Hospital de Jove

Marı́a L. Lamelas · Fundación Hospital de Jove

Francisco J. Vizoso

Abstract

Breast carcinomas with distant metastasis frequently have tumour cells expressing intracellular FN. There is a strong association between FN expression by tumour cells and MMP or TIMP expression by stromal MICs, and this may represent crosstalk that is of prognostic relevance in breast cancer.

Topics & Keywords

Cell Adhesion Molecules Research Protease and Inhibitor Mechanisms Peptidase Inhibition and Analysis

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Histopathology

Volume 64, Issue 4, pp. 512-522

DOI: 10.1111/his.12300

Field-Weighted Citation Impact: 7.40