Microvesicles derived from human Wharton’s Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1

2014280 citationsJournal Articlegold Open Access

Authors

Xiangyu Zou · Shanghai Jiao Tong University

Guangyuan Zhang · Shanghai Jiao Tong University

Zhongliang Cheng · Ningbo No. 2 Hospital

Yin Deming · Shanghai Jiao Tong University

Tao Du · Henan Provincial People's Hospital

Guanqun Ju · Shanghai First People's Hospital

Shuai Miao ·

Abstract

A single administration of MVs immediately after ischemic AKI could ameliorate renal injury in both the acute and chronic stage, and the anti-inflammatory property of MVs through suppression of CX3CL1 may be a potential mechanism. This establishes a substantial foundation for future research and treatment.

Topics & Keywords

Extracellular vesicles in disease MicroRNA in disease regulation Mesenchymal stem cell research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

Volume 5, Issue 2, pp. 40-40

DOI: 10.1186/scrt428

Field-Weighted Citation Impact: 9.53