Prasugrel Compared With High Loading- and Maintenance-Dose Clopidogrel in Patients With Planned Percutaneous Coronary Intervention

2007876 citationsJournal Article

Authors

Stephen D. Wiviott · Florida College

Dietmar Trenk · University of Massachusetts Chan Medical School

Andrew L. Frelinger · Eli Lilly (United States)

Michelle L. O’Donoghue · Massachusetts General Hospital

Franz‐Josef Neumann · Florida College

Alan D. Michelson · Eli Lilly (United States)

Dominick J. Angiolillo

Abstract

Among patients undergoing cardiac catheterization with planned percutaneous coronary intervention, loading with 60 mg prasugrel resulted in greater platelet inhibition than a 600-mg clopidogrel loading dose. Maintenance therapy with prasugrel 10 mg/d resulted in a greater antiplatelet effect than 150 mg/d clopidogrel.

Topics & Keywords

Antiplatelet Therapy and Cardiovascular Diseases Acute Myocardial Infarction Research Coronary Interventions and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 116, Issue 25, pp. 2923-2932

DOI: 10.1161/circulationaha.107.740324

Field-Weighted Citation Impact: 58.06