Single‐marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase

2010447 citationsJournal Articlegreen Open Access

Authors

Matthew R. Clay · University of Wisconsin–Madison

Mark Tabor · University of South Florida

John H. Owen · University of Michigan–Ann Arbor

Thomas E. Carey · University of Michigan–Ann Arbor

Carol R. Bradford · University of Michigan–Ann Arbor

Gregory T. Wolf · University of Michigan–Ann Arbor

Max S. Wicha

Abstract

ALDH(high) cells comprise a subpopulation cells in HNSCCs that are tumorigenic and capable of producing tumors at very low numbers. This finding indicates that ALDH activity on its own is a highly selective marker for CSCs in HNSCC.

Topics & Keywords

Cancer Cells and Metastasis Cancer, Hypoxia, and Metabolism Mesenchymal stem cell research

Publication Details

Published in: Head & Neck

Volume 32, Issue 9, pp. 1195-1201

DOI: 10.1002/hed.21315

Field-Weighted Citation Impact: 18.62

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Single‐marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase

Authors

Abstract

Topics & Keywords

Publication Details