Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects

2011200 citationsJournal Articlegold Open Access

Authors

Gertie Janneke Oostingh · University of Salzburg

Eudald Casals · Institut Català de Nanociència i Nanotecnologia

Paola Italiani · National Research Council

Renato Colognato · Joint Research Centre

René Stritzinger · University of Salzburg

Jessica Ponti · Joint Research Centre

Tobias Pfaller

Abstract

The problems that were encountered in the immunological assay systems used in this study, such as chemical or endotoxin contamination and optical interference caused by the dense material, significantly affected the data obtained. These problems have to be solved to enable the development of reliable assays for the assessment of nano-immunosafety.

Topics & Keywords

Nanoparticles: synthesis and applications Immunotoxicology and immune responses

Publication Details

Published in: Particle and Fibre Toxicology

Volume 8, Issue 1, pp. 8-8

DOI: 10.1186/1743-8977-8-8

Field-Weighted Citation Impact: 8.63

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Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects

Authors

Abstract

Topics & Keywords

Publication Details