A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

2012326 citationsJournal Article

Authors

Wataru Aoi · Kyoto Prefectural University

Yuji Naito · Kyoto Prefectural University of Medicine

Tomohisa Takagi · Kyoto Prefectural University of Medicine

Yuko Tanimura · Kyoto Prefectural University of Medicine

Yoshikazu Takanami · Otsuma Women's University

Yukari Kawai · Louis Pasteur Center for Medical Research

Kunihiro Sakuma

Abstract

These findings suggest that exercise stimulates SPARC secretion from muscle tissues and that SPARC inhibits colon tumorigenesis by increasing apoptosis.

Topics & Keywords

Bone and Dental Protein Studies Muscle metabolism and nutrition Vitamin D Research Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 62, Issue 6, pp. 882-889

DOI: 10.1136/gutjnl-2011-300776

Field-Weighted Citation Impact: 9.50