Effect of () variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers

2005169 citationsJournal Article

Authors

Jae‐Yong Chung · Seoul National University

Joo‐Youn Cho · JW Pharmaceutical (South Korea)

K YU · Seoul National University

Jin‐Tae Kim · JW Pharmaceutical (South Korea)

Dal‐Seok Oh · JW Pharmaceutical (South Korea)

Heechul Jung · Seoul National University

Kyoung Soo Lim ·

Abstract

OATP 1 B 1 variant haplotypes were found to have a significant effect on the pharmacokinetics of pitavastatin. These results suggest that the *15 allele is associated with decreased pitavastatin uptake from blood into hepatocytes and that OATP 1 B 1 genetic polymorphisms have no effect on the pharmacokinetics of pitavastatin lactone.

Topics & Keywords

Drug Transport and Resistance Mechanisms Peroxisome Proliferator-Activated Receptors Cancer, Lipids, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Pharmacology & Therapeutics

Volume 78, Issue 4, pp. 342-350

DOI: 10.1016/j.clpt.2005.07.003

Field-Weighted Citation Impact: 6.75