Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer

2013211 citationsJournal Articlebronze Open Access

Authors

Joo Mi Yi · Johns Hopkins University

Angela A. Guzzetta · Johns Hopkins University

Vasudev J. Bailey · Johns Hopkins University

Stephanie R. Downing · Dongnam Institute of Radiological & Medical Sciences

Leander Van Neste · Johns Hopkins University

Katherine B. Chiappinelli · Johns Hopkins University

Brian P. Keeley

Abstract

Promoter DNA methylation of BNC1 and ADAMTS1 is a potential biomarker to detect early-stage pancreatic cancers. Assaying the promoter methylation status of these genes in circulating DNA from serum is a promising strategy for early detection of pancreatic cancer and has the potential to improve mortality from this disease.

Topics & Keywords

Pancreatic and Hepatic Oncology Research Epigenetics and DNA Methylation Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 19, Issue 23, pp. 6544-6555

DOI: 10.1158/1078-0432.ccr-12-3224

Field-Weighted Citation Impact: 5.24