Thematic review series: The Pathogenesis of Atherosclerosis. Toward a biological network for atherosclerosis

200449 citationsReviewhybrid Open Access

Authors

Anatole Ghazalpour · University of California, Los Angeles

Sudheer Doss · University of California, Los Angeles

Xia Yang · University of California, Los Angeles

Jason E. Aten · University of California, Los Angeles

Edward M. Toomey · University of California, Los Angeles

Atila van Nas · University of California, Los Angeles

Susanna Wang

Abstract

The goal of systems biology is to define all of the elements present in a given system and to create an interaction network between these components so that the behavior of the system, as a whole and in parts, can be explained under specified conditions. The elements constituting the network that influences the development of atherosclerosis could be genes, pathways, transcript levels, proteins, or physiologic traits. In this review, we discuss how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of such networks.

Topics & Keywords

Bioinformatics and Genomic Networks Atherosclerosis and Cardiovascular Diseases Computational Drug Discovery Methods

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Lipid Research

Volume 45, Issue 10, pp. 1793-1805

DOI: 10.1194/jlr.r400006-jlr200

Field-Weighted Citation Impact: 2.04